Synthesis and Antiproliferative Activity of 4-(1H-Benzimidazol-2-yl)-N-{3-[(pyrimidin-2-yl)amino]phenyl}benzamides as Potential Protein Kinase Inhibitors
The results of studying the synthesis and antiproliferative activity of new 4-(1H-benzimidazol-2-yl)benzamides containing pharmacophoric 2aminopyrimidine and pyridine moieties are reported. The target compounds were obtained by the acylation of N-(pyrimidin-2-yl)-m-phenylenediamines with 4-(1H-benzimidazol-2-yl)benzoyl chloride or by the aminolysis 4-(1H-benzimidazol-2-yl)benzoic acid with the same amines. The synthesized compounds were evaluated for their in vitro antiproliferative activity against stable human tumor cell lines K562, HL-60, RPMI 1788, and HeLa.
Authors
- О. В. Панибрат
- Thi‐Kim‐Chi Huynh (ORCID: https://orcid.org/0000-0002-6214-8022)
- А. L. Ermolinskaya
- Thi‐Cam‐Thu Nguyen (ORCID: https://orcid.org/0000-0001-5458-8012)
- Thi‐Kim‐Dung Hoang (ORCID: https://orcid.org/0000-0002-9369-8051)
- Е. В. Королева (ORCID: https://orcid.org/0000-0002-0300-8011)
- Zh. V. Ignatovich
Institutions
- National Academy of Sciences of Belarus (BY)
- Institute of Chemistry of New Materials of the National Academy of Sciences of Belarus (BY)
- Institute of Bioorganic Chemistry (BY)
- Vietnam Academy of Science and Technology (VN)
Publication Details
- Journal
- Russian Journal of Organic Chemistry
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1134/s1070428024604679
- Primary Topic
- Quinazolinone synthesis and applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00