Development of Isosteviol-Based Bifunctional Thiourea Organocatalysts for Michael Addition of Aromatic Ketones and Nitroalkenes
Chiral 1,2-diphenylethylenediamine (DPEN) was introduced into isosteviol-derived thiourea organocatalyst to promote the Michael addition of aromatic ketones and nitroalkenes. Under neutral conditions, the new isosteviol-DPEN thiourea catalyst provides high yield (up to 98%) and enantioselectivity (up to 97%) of the Michael addition products with dual stereoselective control. Furthermore, the isosteviol-DPEN thiourea catalyst showed sufficient recyclability and maintained the stereoselectivity in five reuse cycles.
Authors
- Yuxia Liu (ORCID: https://orcid.org/0000-0003-3575-1181)
- Zhaoyang Fan
- Qi Liu
- Xinyu Dai
- Mingyang Lv (ORCID: https://orcid.org/0009-0003-4878-8255)
Institutions
- Henan University of Engineering (CN)
Publication Details
- Journal
- Russian Journal of Organic Chemistry
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1134/s1070428024603662
- Citations
- 3
- Primary Topic
- Asymmetric Synthesis and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 2.81