Efficacy of Clidinium and Chlordiadepoxide as Add-On Therapy in Gastric Disorders

Background and Aim: The treatment of Gastric disorders is a challenge. Clidinium/chlordiazepoxide is a combination of antispasmodic and anxiolytic drugs that has been used as an adjunct treatment for GERD, Functional Dyspepsia, and Organic dyspepsia in clinical practice with limited supporting evidence of efficacy. The study aims to assess the efficacy and safety of clidinium/chlordiazepoxide as an adjunct treatment to a proton pump inhibitor (PPI) in refractory dyspepsia. Materials and Methods: This prospective, observational, and comparative study was conducted in outpatient and inpatient units of the Gastroenterology Department at a tertiary care hospital. The study was carried out over 6 months, with a sample size of 82 subjects. Results and Discussions: A total of 82 patients were treated with Clidinium/Chlordiazepoxide out of which 42 and 40 were found to be female and male. among 32 patients, the condition after add-on therapy in functional dyspepsia 21(65.6%) improved, and 11(34.4%) remained unchanged. Among 39 patients, the condition after add-on therapy in GERD, 28(71.8%) was improved, 9(23.1%) remained unchanged, and 2(5.1%) was worsened. among 11 patients, the condition after add-on therapy in organic dyspepsia 8(72.7%) improved, and 3(27.3%) remained unchanged. Conclusion: The study revealed promising results for Functional Dyspepsia and Organic Dyspepsia, with a significant proportion of patients experiencing improvement. However, the outcomes for GERD were more varied, with a notable portion of patients showing no change or even worsening symptoms.