Causal Associations Between Pre-Pregnancy Diabetes Mellitus and Pre-Eclampsia Risk: Insights from a Mendelian Randomization Study
Our findings demonstrate a causal relationship between pre-pregnancy diabetes (DM) and obesity and the risk of PE from a genetic epidemiological perspective. Adverse maternal factors, including DM and obesity prior to pregnancy, should be considered in mechanistic studies of PE. In addition, comprehensive interventions for risk factors such as pre-pregnancy DM and obesity should be emphasized in clinical practice.
Authors
- Ying Xiang (ORCID: https://orcid.org/0000-0002-4879-2751)
- Quanfeng Wu
- Li Gao (ORCID: https://orcid.org/0000-0003-2927-1827)
- Xiaona Xu (ORCID: https://orcid.org/0000-0001-5861-9402)
- Renyi Hua (ORCID: https://orcid.org/0000-0002-6556-737X)
- Yanlin Wang (ORCID: https://orcid.org/0000-0003-2639-6536)
- Xiaohan Li (ORCID: https://orcid.org/0000-0003-4786-0190)
- Shushu Yu
- Xiaotian Li (ORCID: https://orcid.org/0000-0002-9131-304X)
- Yan Bi
Institutions
- Shanghai Jiao Tong University (CN)
- Xiamen University (CN)
- Shenzhen Maternity and Child Healthcare Hospital (CN)
- International Peace Maternity & Child Health Hospital (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Healthcare
- Published
- 2025-05-07
- DOI
- https://doi.org/10.3390/healthcare13091085
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China