Human menstrual blood-derived stem cells secreted ECM1 directly interacts with LRP1α to ameliorate hepatic fibrosis through FoxO1 and mTOR signaling pathway
These findings highlight an extensive network of ECM1-LRP1 interaction, which serve as a link for providing promising insights into the mechanism of MenSC-based drug development for liver fibrosis. Our study also potentially presents novel avenues for clinical antifibrotic therapy.
Authors
- Sining Zhou (ORCID: https://orcid.org/0000-0003-3680-2307)
- Yin Yuan (ORCID: https://orcid.org/0000-0003-0078-8769)
- Yangxin Fang
- Jiamin Fu (ORCID: https://orcid.org/0000-0002-7700-9615)
- Charlie Xiang (ORCID: https://orcid.org/0000-0002-9193-3900)
- Yifei Li (ORCID: https://orcid.org/0009-0000-1136-6305)
- Lijun Chen (ORCID: https://orcid.org/0000-0001-9374-6466)
- Ning Zhang (ORCID: https://orcid.org/0000-0001-7182-0100)
- Lin Chen (ORCID: https://orcid.org/0000-0002-1587-7564)
- Qi Zhang (ORCID: https://orcid.org/0000-0002-0633-4314)
- Yuqi Huang (ORCID: https://orcid.org/0009-0006-6737-2572)
- Li Yuan (ORCID: https://orcid.org/0009-0001-6417-7791)
Institutions
- Shandong University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- National Center for Infectious Diseases (US)
- Zhejiang Medicine (China) (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1186/s13287-025-04351-0
- Citations
- 3
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 3.97