White matter hyperintensities, inflammation and cognitive impairments in drug-naïve first episode schizophrenia patients: a cross-sectional study
This study suggests that WMHs may play a vital mediating role in the relationship between inflammation, oxidative stress, and cognitive impairments in SCH. Future studies exploring the potential clinical utility of WMHs as biomarkers for early detection and intervention of SCH are warranted.
Authors
- Xueqin Song (ORCID: https://orcid.org/0000-0001-9830-7155)
- Xiaoduo Fan (ORCID: https://orcid.org/0000-0003-4299-8924)
- Kangkang Xue (ORCID: https://orcid.org/0000-0002-7110-8647)
- Suying Ding
- Yishao Chen
- Xiuxia Yuan (ORCID: https://orcid.org/0000-0001-8124-3052)
- Yu Zhang (ORCID: https://orcid.org/0000-0002-8345-3835)
- Yan Zhang (ORCID: https://orcid.org/0000-0002-2059-4171)
- Jingfeng Chen (ORCID: https://orcid.org/0000-0002-8035-7629)
- Keju Su
Institutions
- University of Massachusetts Chan Medical School (US)
- Zhengzhou University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- UMass Memorial Medical Center (US)
Publication Details
- Journal
- BMC Psychiatry
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1186/s12888-025-06905-1
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Zhengzhou University
- First Affiliated Hospital of Zhengzhou University
- National Key Research and Development Program of China
- Henan Provincial Science and Technology Research Project