Retroelement co-option disrupts the cancer transcriptional programme
These findings underscore the gene-disruptive potential of seemingly innocuous germline RTE integrations, unleashed only by their transcriptional utilisation in cancer. They further suggest that such metastable RTE integrations are co-opted as sensors of the epigenetic and transcriptional changes occurring during cellular transformation and as executors that disrupt the function of tumour-promoting genes.
Authors
- Judith Pape (ORCID: https://orcid.org/0000-0002-4225-5568)
- Laura Doglio
- Callum Hall (ORCID: https://orcid.org/0000-0002-0491-4438)
- Jane Ho Chun Loong (ORCID: https://orcid.org/0000-0001-8718-6677)
- George Kassiotis (ORCID: https://orcid.org/0000-0002-8457-2633)
- R. Houston Thompson (ORCID: https://orcid.org/0009-0000-7536-523X)
- Tobias Plowman (ORCID: https://orcid.org/0000-0002-0413-0975)
Institutions
- The Francis Crick Institute (GB)
Publication Details
- Journal
- Genome Medicine
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1186/s13073-025-01479-9
- Citations
- 3
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Francis Crick Institute
- HORIZON EUROPE European Research Council