Silencing of Rac1 and Arf6 reduces time-dependent and carbachol-induced contractions, proliferation, survival and growth in human bladder smooth muscle cells
Arf6 and Rac1 promote time-dependent and carbachol-induced contractions of hBSMC, which may be mediated by actin polymerization. Simultaneously, Arf6 and Rac1 promote proliferation, growth and survival in hBSMC. Arf6 and Rac1 may be potentially involved in detrusor overactivity, bladder wall thickening and medical treatment of overactive bladder.
Authors
- Martin Hennenberg (ORCID: https://orcid.org/0000-0003-1305-6727)
- Wenbin Zhu (ORCID: https://orcid.org/0000-0001-9158-335X)
- Christian Georg Stief (ORCID: https://orcid.org/0000-0003-3291-9460)
- Alexander Tamalunas
- Sheng Hu (ORCID: https://orcid.org/0000-0001-6046-3478)
- Siwei Qian
Institutions
- LMU Klinikum (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- World Journal of Urology
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1007/s00345-025-05652-y
- Citations
- 1
- Primary Topic
- Urinary Bladder and Prostate Research
- Type
- article
- Field-Weighted Citation Impact
- 1.84