Neoadjuvant Radiotherapy vs Up-Front Surgery for Resectable Locally Advanced Rectal Cancer
In this cohort study of nationwide registries in Taiwan, NRT followed by surgery was associated with improved oncological outcomes for overall resectable LARC, with excessive diverting stoma nonreversal as the trade-off. However, the benefits of NRT were not observed for upper rectal cancer. These findings raise concerns about potential harm from NRT and advise caution when performing NRT for upper rectal cancer.
Authors
- M. Tsai (ORCID: https://orcid.org/0000-0002-3203-5983)
- Alessandro Fichera (ORCID: https://orcid.org/0000-0003-4205-4413)
- Edward Chia‐Cheng Lai (ORCID: https://orcid.org/0000-0002-5852-7652)
- Chao‐Han Lai (ORCID: https://orcid.org/0000-0002-1382-1495)
- Yu Shyr (ORCID: https://orcid.org/0000-0003-2086-9670)
- Avery Shuei‐He Yang (ORCID: https://orcid.org/0000-0002-1674-0148)
- Yu‐Min Yeh (ORCID: https://orcid.org/0000-0003-1905-5872)
- Yuan-Hua Wu
- Po-Chuan Chen
Institutions
- Cornell University (US)
- National Cheng Kung University Hospital (TW)
- Weill Cornell Medicine (US)
- Vanderbilt University Medical Center (US)
- National Cheng Kung University (TW)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.9049
- Citations
- 2
- Primary Topic
- Colorectal Cancer Surgical Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- Ministry of Science and Technology, Taiwan
- National Cheng Kung University Hospital
- National Cheng Kung University
- National Science and Technology Council