P4HA1 Mediates Hypoxia-Induced Invasion in Human Pancreatic Cancer Organoids
This study demonstrates that hypoxia increases invasion across a cohort of human pancreatic cancer organoids and identifies the collagen-modifying enzyme P4HA1 as a driver of hypoxia-enhanced invasion. These results characterize a molecular mechanism by which the microenvironment alters tumor cell behavior and underscore new strategies to inhibit invasion.
Authors
- Fatemeh Shojaeian (ORCID: https://orcid.org/0000-0001-5972-9953)
- Daniele M. Gilkes (ORCID: https://orcid.org/0000-0003-3984-9338)
- Maria F. Wissler (ORCID: https://orcid.org/0000-0003-0840-8644)
- Elana J. Fertig (ORCID: https://orcid.org/0000-0003-3204-342X)
- Laura DeLong Wood (ORCID: https://orcid.org/0000-0003-3096-652X)
- Vania Wang (ORCID: https://orcid.org/0000-0002-9428-7019)
- Hildur Knútsdóttir (ORCID: https://orcid.org/0000-0001-5949-3450)
- Joel S. Bader (ORCID: https://orcid.org/0000-0002-6020-4625)
- Michael G. Lerner (ORCID: https://orcid.org/0000-0003-1222-3212)
- Alana M. Weaver
- Saravana Gowtham Baskaran (ORCID: https://orcid.org/0000-0002-7382-7418)
- Bernat Navarro-Serer (ORCID: https://orcid.org/0000-0002-3001-4951)
- Brandi K. Glover (ORCID: https://orcid.org/0000-0002-5760-8143)
- Sarah Hughes
- Kathleen Noller (ORCID: https://orcid.org/0000-0001-7915-3269)
- Harsh H. Oza (ORCID: https://orcid.org/0000-0001-6724-5975)
- Oluwatobiloba Olayemi (ORCID: https://orcid.org/0009-0005-5638-0983)
- Daniel Wilentz
Institutions
- University of Maryland, Baltimore (US)
- Earlham College (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- University of Baltimore (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1158/2767-9764.crc-24-0025
- Citations
- 2
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.87