The 2016 CDC Opioid Guideline and Analgesic Prescribing Patterns in Older Adults With Cancer
In this cohort study of older adults with cancer, the 2016 CDC guideline was associated with a decline in opioid prescribing that was less pronounced for tramadol compared with typical opioids and was followed by a 25% increase in gabapentinoid prescribing. This may reflect a shift in cancer pain management from first-line opioids to tramadol, which is less safe, and gabapentinoids, which have been shown to be less effective for cancer pain treatment.
Authors
- Rebecca Rodin (ORCID: https://orcid.org/0000-0003-2984-3514)
- Cardinale B. Smith (ORCID: https://orcid.org/0000-0003-3635-8701)
- Ulrike Muench (ORCID: https://orcid.org/0000-0003-0754-664X)
- Karen McKendrick (ORCID: https://orcid.org/0000-0003-3452-8770)
- Krista L. Harrison (ORCID: https://orcid.org/0000-0001-5373-3011)
- Lauren J. Hunt (ORCID: https://orcid.org/0000-0002-2731-2173)
- R. Sean Morrison (ORCID: https://orcid.org/0000-0003-0830-5100)
- Melissa D. Aldridge (ORCID: https://orcid.org/0000-0002-3334-4542)
- Lihua Li (ORCID: https://orcid.org/0000-0003-3154-9576)
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- University of California, San Francisco (US)
- James J. Peters VA Medical Center (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.9043
- Citations
- 3
- Primary Topic
- Opioid Use Disorder Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- Centers for Disease Control and Prevention