Assessment of Pharmacological Interventions of Chronic Alcoholic Liver Disease and Their Clinical Outcomes

Abstract: Background and Aim: This study aims to evaluate the effectiveness of pharmacological interventions for chronic ALD, analyze the demographic and clinical profile of ALD patients, assess the associated complications, and investigate the prescription patterns of drugs used in ALD treatment. Methods and materials: This prospective observational study was conducted in the outpatient and inpatient units of the Department of Gastroenterology at a tertiary care hospital. The study was carried out over a 6-month period, with a total sample size of 64 subjects. Results and discussion: The study focuses on 64 subjects with ALD, recommending nutritional support(76.6%), alcohol abstinence(95.3%), ursodeoxycholic acid(60.9%), antibiotics(42.2%), and benzodiazepines(25%) for management and prognosis. Liver transplant is the only viable treatment, with hepatologists and addiction specialists providing integrated therapy. Out of 16 alcoholic hepatitis patients, 56.3% improved, 43.8% had persistent conditions, and 83.3% improved in compensated disease state. Conclusion: The study found that alcohol abstinence, along with nutritional and pharmacological therapy, improves quality of life in compensated ALD. Liver transplantation is an option for advanced cases. Psychological and pharmacological support aid in abstinence, though alcohol withdrawal can cause behavioral, gastrointestinal, and neurological issues.