<i>APOE4</i> , Blood Neurodegenerative Biomarkers, and Cognitive Decline in Community-Dwelling Older Adults
This study found that higher levels of neurodegeneration (t-tau), axonal injury (NfL), and reactive astrocytes and neuroinflammation (GFAP) biomarkers were associated with accelerated cognitive decline in genetically susceptible APOE4 carriers. These findings highlight the association of APOE4 with exacerbation of neurodegenerative processes, with not only significant implications for understanding and tracking the progression of neurodegenerative diseases, but also a call for inclusivity of APOE4 status in scientific investigations and clinical trials.
Authors
- Ted Kheng Siang Ng (ORCID: https://orcid.org/0000-0001-7348-0410)
- Todd Beck (ORCID: https://orcid.org/0000-0001-8781-2105)
- Patricia Boyle
- Klodian Dhana (ORCID: https://orcid.org/0000-0002-6397-7009)
- Kumar B. Rajan (ORCID: https://orcid.org/0000-0001-7685-2101)
- Denis A. Evans
- Pankaja Desai
Institutions
- Rush University Medical Center (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.8903
- Citations
- 13
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 19.13
Funders
- Alzheimer's Association
- Rush University
- National Institutes of Health