Immunodynamic axis of fibroblast-driven neutrophil infiltration in acute pancreatitis: NF-κB–HIF-1α–CXCL1
This study, for the first time, demonstrated that activation of fibroblasts is one of the immunological driving factors for neutrophil infiltration and elucidated that glycolysis driven by the NF-κB-HIF-1α pathway is the intrinsic molecular mechanism by which fibroblasts secrete CXCL1 to chemotactically attract neutrophils. This finding provides a highly promising target for the treatment of AP.
Authors
- Dongbo Xue (ORCID: https://orcid.org/0000-0001-9012-4805)
- Xiao Zhang (ORCID: https://orcid.org/0000-0003-1706-2868)
- Yi Zheng (ORCID: https://orcid.org/0000-0002-4877-4289)
- Chenglong Han
- Xuxu Liu (ORCID: https://orcid.org/0000-0001-5408-4746)
- Zhenyi Lv
- Qiang Wang (ORCID: https://orcid.org/0000-0002-2564-1491)
- Tao Li (ORCID: https://orcid.org/0000-0002-5100-4429)
- Tianming Liu (ORCID: https://orcid.org/0000-0001-5850-666X)
- Zhiwei Du
- Liyi Wang
Institutions
- Harbin Medical University (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1186/s11658-025-00734-6
- Citations
- 13
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 26.08
Funders
- Key Research and Development Program of Heilongjiang
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Postdoctoral Innovation Project of Shandong Province
- National Key Research and Development Program of China