Pentraxin 3 promotes the expression of pro-inflammatory cytokines and the migration of macrophages in myocarditis
Our findings suggest that PTX3-mediated NLRP3 activation contributes to inflammatory responses and promotes macrophage migration in myocarditis. This study provides a foundation for future investigations into PTX3-targeted therapies for myocarditis.
Authors
- Xuezhi Chen (ORCID: https://orcid.org/0000-0002-7421-6985)
- Ying Ding (ORCID: https://orcid.org/0000-0003-2567-2009)
- Tianyu Zhu (ORCID: https://orcid.org/0009-0003-7837-9647)
- Xiaohui Liu (ORCID: https://orcid.org/0000-0002-2693-4827)
- Ning Wang (ORCID: https://orcid.org/0000-0003-1410-329X)
- Wenchao Zhang (ORCID: https://orcid.org/0000-0002-8752-2690)
- Yang Quan
- Yan Li (ORCID: https://orcid.org/0000-0002-7257-7859)
- Xiaohui Wu (ORCID: https://orcid.org/0000-0002-1801-9645)
- Guanliang Cheng
Institutions
- Peking University (CN)
- Chinese PLA General Hospital (CN)
- Peking University International Hospital (CN)
Publication Details
- Journal
- BMC Cardiovascular Disorders
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1186/s12872-025-04790-w
- Citations
- 3
- Primary Topic
- Biomarkers in Disease Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- National Natural Science Foundation of China
- Peking University