Histone Deacetylase 6 Brain PET in Amyotrophic Lateral Sclerosis‐Frontotemporal Spectrum Disorder
[<sup>18</sup>F]EKZ-001 binding is lower throughout the brain in pwALS compared to HC. This may be related to a compensatory mechanism to repair intracellular transport defects in ALS or to reduced HDAC6 enzyme availability for [<sup>18</sup>F]EKZ-001 binding due to sequestration of HDAC6 within protein aggregates.
Authors
- Philip Van Damme (ORCID: https://orcid.org/0000-0002-4010-2357)
- Frederick A. Schroeder (ORCID: https://orcid.org/0000-0003-0469-4196)
- Janice E. Kranz (ORCID: https://orcid.org/0000-0003-2629-5583)
- Jacob M. Hooker (ORCID: https://orcid.org/0000-0002-9394-7708)
- Fouke Ombelet (ORCID: https://orcid.org/0000-0003-1530-0869)
- Tonya M. Gilbert (ORCID: https://orcid.org/0000-0002-9198-1419)
- Joke De Vocht (ORCID: https://orcid.org/0000-0003-4116-192X)
- C P Carron (ORCID: https://orcid.org/0000-0002-6561-0104)
- Greet Vanderlinden (ORCID: https://orcid.org/0000-0002-5673-4121)
- Michel Koole (ORCID: https://orcid.org/0000-0001-5862-640X)
- Lauren Jayne Evans
- Koen Van Laere (ORCID: https://orcid.org/0000-0001-5200-7245)
- Pegah Masrori (ORCID: https://orcid.org/0000-0001-8247-1866)
- Donatienne Van Weehaeghe (ORCID: https://orcid.org/0000-0001-6646-106X)
- Rebecca E. James
- Caro De Weerdt
Institutions
- Cliniques Universitaires Saint-Luc (BE)
- Universitair Ziekenhuis Leuven (BE)
- Ghent University Hospital (BE)
- VIB-KU Leuven Center for Brain & Disease Research (BE)
- KU Leuven (BE)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1002/acn3.70067
- Citations
- 1
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Association for Frontotemporal Degeneration
- Target ALS
- Eikonizo Therapeutics
- KU Leuven