Temporal transcriptomic changes in the THY-Tau22 mouse model of tauopathy display cell type- and sex-specific differences
This study provides a comprehensive single-cell transcriptomic characterization of sex-linked and age-dependent changes in the THY-Tau22 tauopathy model, revealing new insights into the interplay between age-dependent AD-like pathologies and sex. The identified sex-specific changes and their conservation across models and human AD highlight molecular targets for further preclinical investigation of sex-specific therapeutic strategies in AD.
Authors
- Manuel Buttini (ORCID: https://orcid.org/0000-0003-1805-0279)
- Rashi Halder (ORCID: https://orcid.org/0000-0002-1402-1254)
- Laetitia Lunkes
- Pierre Garcia (ORCID: https://orcid.org/0000-0002-6681-9671)
- Tony Heurtaux (ORCID: https://orcid.org/0000-0002-1709-5312)
- Muhammad Ali (ORCID: https://orcid.org/0000-0002-1399-6631)
- Luc Buée (ORCID: https://orcid.org/0000-0002-6261-4230)
- David L Blum (ORCID: https://orcid.org/0000-0001-5691-431X)
- Alexander Skupin (ORCID: https://orcid.org/0000-0002-8955-8304)
- Enrico Glaab (ORCID: https://orcid.org/0000-0003-3977-7469)
- Kamil Grzyb (ORCID: https://orcid.org/0000-0002-2416-9500)
- Alessia Sciortino (ORCID: https://orcid.org/0009-0005-8770-3490)
- Mélanie H. Thomas (ORCID: https://orcid.org/0000-0003-0328-6406)
Institutions
- Inserm (FR)
- University of Luxembourg (LU)
- Université de Lille (FR)
- Centre Hospitalier Universitaire de Lille (FR)
Publication Details
- Journal
- Acta Neuropathologica Communications
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1186/s40478-025-02013-z
- Citations
- 2
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.68
Funders
- Université du Luxembourg
- Fonds National de la Recherche Luxembourg