Inositol-Requiring Enzyme 1 pathway and autophagy drive sequential response of endothelial cells to febrile range hyperthermia
Our findings reveal that in response to fever-range hyperthermia, the IRE1α-autophagy axis regulates the survival and function of coronary endothelial cells. This mechanism could play a key role in modulating endothelial responses during infection and contribute to the pathological outcomes of fever. Furthermore, it may be relevant in local inflammatory conditions with elevated temperatures.
Authors
- G Franck (ORCID: https://orcid.org/0000-0002-4288-9034)
- C. Giuseppina
- Marie Le Borgne (ORCID: https://orcid.org/0000-0002-3439-4867)
- Corinne Rocher (ORCID: https://orcid.org/0000-0001-6656-3955)
- Stéphane Illiano (ORCID: https://orcid.org/0000-0001-9196-0493)
- Julie Vorbe
- Antonino Nicoletti (ORCID: https://orcid.org/0000-0002-2623-0897)
- Florence Massey
- Océane Morales
- Nihal Brikci
Institutions
- Inserm (FR)
- Université Paris Cité (FR)
- Sanofi (France) (FR)
- Sorbonne Université (FR)
- Université Sorbonne Paris Nord (FR)
- Sorbonne Paris Cité (FR)
- Laboratoire de Recherche Vasculaire Translationnelle (FR)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1371/journal.pone.0315119
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Sanofi
- Agence Nationale de la Recherche