Identification and validation of diagnostic markers and drugs for pediatric bronchopulmonary dysplasia based on integrating bioinformatics and molecular docking analysis
In conclusion, our results show that IL7R, CXCL10, DEFA4, PRTN3, NCAPG and CCNB1 are BPD diagnostic indicators, and revealing immunological features associated with BPD. The molecular interactions of resveratrol and progesterone with the aforementioned key targets suggest their potential as therapeutic drugs for treating BPD.
Authors
- Qirui Zheng
- Liang Zhang (ORCID: https://orcid.org/0000-0001-6273-8375)
- Rui Guo (ORCID: https://orcid.org/0009-0007-5140-5373)
Institutions
- Liaoning Provincial People's Hospital (CN)
- First Hospital of China Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1371/journal.pone.0323006
- Citations
- 1
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 1.52