G-LERP/miR-374i-b Attenuates IRI and Suppresses Hepatocellular Carcinoma Progression
This research is the first to demonstrate miR-374b-5p as a dual therapeutic target during LT and postoperative recurrence of HCC. Preintervention of miR-374b-5p using an esterase-responsive gene delivery system during the preoperative period simultaneously alleviates IRI and suppresses HCC progression.
Authors
- Xiao Xu (ORCID: https://orcid.org/0000-0002-2761-2811)
- Nasha Qiu (ORCID: https://orcid.org/0000-0002-6240-0857)
- Hengkai Zhu
- Chang Xie
- Zhengxing Lian (ORCID: https://orcid.org/0000-0001-8418-4916)
- Haitao Hu (ORCID: https://orcid.org/0000-0002-1984-5842)
- Siyu Chen (ORCID: https://orcid.org/0009-0002-1890-799X)
- Hui Zhang (ORCID: https://orcid.org/0000-0001-6825-5649)
- Chao Wang (ORCID: https://orcid.org/0009-0002-7096-8896)
- Jun Chen (ORCID: https://orcid.org/0000-0002-9430-777X)
- Yiyang Sun
- Xinfeng Lu
Institutions
- Zhejiang International Studies University (CN)
- Zhejiang Chinese Medical University (CN)
- Hangzhou Normal University (CN)
- Westlake University (CN)
- Zhejiang Shuren University (CN)
- Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Transplantation
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1097/tp.0000000000005412
- Citations
- 2
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.87