Inner Ear Pathologies After Cochlear Implantation in Guinea Pigs: Functional, Histopathological, and Endoplasmic Reticulum Stress-Mediated Apoptosis
Our study highlights the various effects of CI surgery on cochlear and vestibular function and morphology in guinea pigs. ER stress-mediated apoptosis may contribute to secondary cochlear damage, whereas the vestibular system demonstrates adaptive responses that preserve cellular homeostasis. These findings provide insights into potential mechanisms underlying inner ear complications post-CI.
Authors
- Qing Zhang (ORCID: https://orcid.org/0000-0002-5200-3356)
- Shuyun Liu (ORCID: https://orcid.org/0000-0003-3865-4547)
- Yuzhong Zhang (ORCID: https://orcid.org/0000-0001-7116-9135)
- Qingqing Dai
- Qiong Wu (ORCID: https://orcid.org/0000-0003-1943-985X)
- Yu Zhao (ORCID: https://orcid.org/0009-0000-5444-4078)
- Yulian Jin (ORCID: https://orcid.org/0000-0002-4589-0874)
Institutions
- Sichuan University (CN)
- XinHua Hospital (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- West China Hospital of Sichuan University (CN)
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Ear and Hearing
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1097/aud.0000000000001668
- Primary Topic
- Hearing, Cochlea, Tinnitus, Genetics
- Type
- article
- Field-Weighted Citation Impact
- 0.00