Mapping the genetic landscape of immune-mediated disorders: potential implications for classification and therapeutic strategies
Our findings support a polygenic continuum across immune-mediated disorders, with four genetic clusters. The "polygenic autoimmune" and "polygenic autoinflammatory" clusters reside on margins of this continuum. These findings provide insights and lead us to hypothesize that the identified clusters could inform future therapeutical strategies, with patients in the same clusters potentially responding similarly to specific therapies.
Authors
- Olav B. Smeland (ORCID: https://orcid.org/0000-0002-3761-5215)
- Piotr Jahołkowski (ORCID: https://orcid.org/0000-0001-9408-3107)
- Ole A. Andreassen (ORCID: https://orcid.org/0000-0002-4461-3568)
- Erik D Wiström (ORCID: https://orcid.org/0009-0000-4498-9795)
- Julian Fuhrer (ORCID: https://orcid.org/0000-0001-6286-5614)
- Vera Fominykh (ORCID: https://orcid.org/0000-0001-5490-2390)
- Alexey A. Shadrin (ORCID: https://orcid.org/0000-0002-7467-250X)
- Srdjan Djurovic (ORCID: https://orcid.org/0000-0002-8140-8061)
- Helga Sanner (ORCID: https://orcid.org/0000-0001-7226-066X)
- Nadine Parker (ORCID: https://orcid.org/0000-0002-8369-0152)
- Oleksandr Frei (ORCID: https://orcid.org/0000-0002-6427-2625)
Institutions
- Oslo University Hospital (NO)
- OsloMet – Oslo Metropolitan University (NO)
- University of Oslo (NO)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1543781
- Citations
- 4
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.19