Case Report: A rare case of renal failure secondary to in utero megalourethra

Unlike previously described cases, this case is unique due to the patient's abrupt progression to anhydramnios at 34 weeks and 5 days, despite having normal amniotic fluid levels prior to that. With late-onset anhydramnios, the severity of renal dysfunction was unexpected. Proximal urethrostomy requires further assessment as a potential intervention to successfully bypass the megalourethra and prevent infection. Long-term management is expected to include dialysis as a bridge to transplantation. Multiple corrective urological surgeries will be required to repair the urethra and restore penile function. Timely prenatal diagnosis of megalourethra or renal anomalies is essential for predicting long-term prognosis, as these conditions can lead to significant postnatal complications.

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Publication Details

Journal
Frontiers in Pediatrics
Published
2025-05-08
DOI
https://doi.org/10.3389/fped.2025.1546561
Primary Topic
Ureteral procedures and complications
Type
article
Field-Weighted Citation Impact
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article

Case Report: A rare case of renal failure secondary to in utero megalourethra

Chryso Katsoufis, Carolyn Abitbol, Rayan S. Terkawi, Sana Barkat Ali et al.
Frontiers in Pediatrics
Ureteral procedures and complications
article

Case Report: A rare case of renal failure secondary to in utero megalourethra

Chryso Katsoufis, Carolyn Abitbol, Rayan S. Terkawi, Sana Barkat Ali, Tania D. Fontánez-Nieves, Rodrigo Ruano, Joanne Duara
article en

Abstract

Unlike previously described cases, this case is unique due to the patient's abrupt progression to anhydramnios at 34 weeks and 5 days, despite having normal amniotic fluid levels prior to that. With late-onset anhydramnios, the severity of renal dysfunction was unexpected. Proximal urethrostomy requires further assessment as a potential intervention to successfully bypass the megalourethra and prevent infection. Long-term management is expected to include dialysis as a bridge to transplantation. Multiple corrective urological surgeries will be required to repair the urethra and restore penile function. Timely prenatal diagnosis of megalourethra or renal anomalies is essential for predicting long-term prognosis, as these conditions can lead to significant postnatal complications.

Frontiers in PediatricsVol. 13
University of Miami Hospital (US)
Openalex Percentile: Top 87%
Ureteral procedures and complications
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Case Report: A rare case of renal failure secondary to in utero megalourethra — Chryso Katsoufis, Carolyn Abitbol, et al. · Frontiers in Pediatrics (2025) | TGRS Research Map | TGRS