Nerve injury induces pain hypersensitivity and anxiety-related behaviours and is associated with amygdala activation in male mice
The BLA and CeA showed activation in chronic pain and associated anxiety, and there were spatial differences in this activation. Targeting the amygdala may hold promise for treating chronic nerve pain with anxiety-like behaviors.
Authors
- Siyuan Tong (ORCID: https://orcid.org/0000-0001-6517-6208)
- Yuyang Wei (ORCID: https://orcid.org/0000-0002-3200-8598)
- Xirui Wang (ORCID: https://orcid.org/0000-0003-4484-5390)
- Yuanyuan Wu (ORCID: https://orcid.org/0000-0001-8884-0802)
- Lin‐Xiao Wang (ORCID: https://orcid.org/0009-0006-5016-4312)
- Yuerong Chen
- Zonglin Wu
Institutions
- The Third Affiliated Hospital of Zhejiang Chinese Medical University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1371/journal.pone.0323203
- Citations
- 1
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- National Natural Science Foundation of China