Association between Perfluorooctanoic Acid–Related Poor Embryo Quality and Metabolite Alterations in Human Follicular Fluid during IVF: A Cohort Study
High exposure to follicular fluid PFAS was negatively correlated with embryo quality during ART, with PFOA likely to be the major contributor. PFOA-related poor embryo quality was associated with the reduction of organonitrogens and sphingolipids metabolites that are crucial for the maintenance of normal cell growth and metabolism. https://doi.org/10.1289/EHP15422.
Authors
- Pengcheng Kong
- Yi Guo (ORCID: https://orcid.org/0000-0003-0083-8308)
- Junting Xu (ORCID: https://orcid.org/0000-0002-7788-9026)
- Lingling Wang (ORCID: https://orcid.org/0000-0003-0272-2974)
- Wenqiang Liu (ORCID: https://orcid.org/0000-0001-5028-0467)
- Kunming Li (ORCID: https://orcid.org/0000-0002-4636-9634)
- Wanli Yang (ORCID: https://orcid.org/0000-0002-3053-9686)
- Xiaoming Teng
- Xianting Jiao (ORCID: https://orcid.org/0009-0003-2801-3196)
- Siyu Chen (ORCID: https://orcid.org/0009-0000-8758-3672)
Institutions
- Tongji University (CN)
- Shanghai Jiao Tong University (CN)
- XinHua Hospital (CN)
Publication Details
- Journal
- Environmental Health Perspectives
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1289/ehp15422
- Citations
- 10
- Primary Topic
- Per- and polyfluoroalkyl substances research
- Type
- article
- Field-Weighted Citation Impact
- 8.60
Funders
- National Natural Science Foundation of China