Association between FcγRIIB Gene Polymorphism, Periodontitis and Pregnancy-induced Hypertension in Chinese Pregnancy Women

Objective: Research suggests a link between maternal periodontitis and pregnancy-induced hypertension (PIH). As an immunoglobulin G (IgG) receptor, FcγRIIB delivers inhibitory signals to B lymphocytes. Previous studies have demonstrated that FcγRIIB-232I/T polymorphism is associated with periodontitis, and the link between 232T allele carriers and periodontitis may stem from their reduced IgG antibody responses to P. gingivalis. The role of FcγRIIB-232I/T polymorphism in predisposing Chinese pregnant women to periodontitis and PIH was explored in this investigation. Methods: Clinical periodontal parameters and obstetric records were retrospectively analyzed in 87 Chinese pregnant women. FcγRIIB-232I/T genotyping was performed using genomic DNA isolated from peripheral blood samples from each participant. The expression levels of FcγRIIb on peripheral B lymphocytes from 10 women were measured by flow cytometry. Results: The FcγRIIB-232T allele was associated with elevated third-trimester blood pressure, with compounded effects observed in carriers concurrently affected by periodontitis. Periodontitis and PIH exhibited a shared genetic predisposition through the FcγRIIB-232I/T polymorphic locus. Among individuals carrying the FcγRIIB-232T allele, periodontitis was significantly associated with PIH. Conclusion: FcγRIIB-232T allele carriers of Chinese pregnancy women are more susceptible to periodontitis and PIH,and those with periodontitis are more susceptible to PIH.