Oocytes With Impaired Meiotic Maturation Contain Increased mtDNA Deletions
(Abstracted from J Assist Reprod Genet 2025;42:753–762) Oxidative phosphorylation (OXPHOS) occurs within the mitochondria to produce ATP and is driven by mitochondrial DNA (mtDNA). Mutations in mtDNA have been associated with rare genetic disorders as well as cellular dysfunction, with these mutations often attributable to limited capacity for DNA repair and proximity to reactive oxygen species generated during OXPHOS.
Authors
- Jason D. Kofinas
- J. Grifo (ORCID: https://orcid.org/0000-0003-0439-2374)
- M.L. Seth-Smith
- Johanna Van Den Daele (ORCID: https://orcid.org/0000-0001-8879-4551)
- David H. McCulloh (ORCID: https://orcid.org/0000-0001-5217-8917)
- David L. Keefe (ORCID: https://orcid.org/0000-0001-6704-6343)
- Fang Wang (ORCID: https://orcid.org/0000-0002-0862-696X)
- Y.G. Kramer
Publication Details
- Journal
- Obstetrical & Gynecological Survey
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1097/ogx.0000000000001400
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 0.00