Rescue In Vitro Maturation Using Ovarian Support Cells of Human Oocytes From Conventional Stimulation Cycles Yields Oocytes With Improved Nuclear Maturation and Transcriptomic Resemblance to In Vivo Matured Oocytes
(Abstracted from J Assist Reprod Genet 2024;41(8):2021–2036) Embryo development is orchestrated by several somatic types of ovarian cells, including stroma, theca, and granulosa cells that each send signals to oocytes; during oocyte maturation, oocytes rely on posttranscriptional modification, transcript degradation, and selective translation. There is little literature to date that has focused on transcriptome-wide changes in gene expression in oocytes after in vitro maturation (IVM), although the mechanisms of maturation may differ in vitro versus in vivo.
Authors
- Alexa Giovannini
- Dawn A. Kelk
- Pranam Chatterjee (ORCID: https://orcid.org/0000-0003-3957-8478)
- Pedro Belchin
- Joseph A. Lee (ORCID: https://orcid.org/0000-0002-2739-2695)
- Maria Marchante
- Samantha L. Estevez (ORCID: https://orcid.org/0000-0003-0954-5819)
- Merrick Pierson Smela (ORCID: https://orcid.org/0000-0001-5816-7098)
- Alan B. Copperman
- David H. McCulloh (ORCID: https://orcid.org/0000-0001-5217-8917)
- Caroline Aschenberger
- Graham Rockwell
- Kathryn Potts (ORCID: https://orcid.org/0000-0002-3246-9597)
- Shelby Marcinyshyn
- Daniel Ordonez-Perez
- Erkan Büyük (ORCID: https://orcid.org/0000-0001-6083-4320)
- Christian Kramme (ORCID: https://orcid.org/0000-0002-7518-8111)
- Simone Kats (ORCID: https://orcid.org/0000-0002-3231-3525)
- Sabrina Piechota
- Patrick R.J. Fortuna (ORCID: https://orcid.org/0000-0003-2296-1120)
- Alexandra B Figueroa
- Marta Sanchez
- Ferran Barrachina (ORCID: https://orcid.org/0000-0003-3138-4142)
- Alexander D. Noblett (ORCID: https://orcid.org/0000-0002-3232-7951)
- Marcy Forti
- Bruna Paulsen (ORCID: https://orcid.org/0000-0001-5304-0610)
- Klaus Wiemer
- Rick E. Slifkin
- Joshua U. Klein
Publication Details
- Journal
- Obstetrical & Gynecological Survey
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1097/01.ogx.0001113800.79183.83
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 0.00