Respiratory safety pharmacology study of single oral administration of pentoxifylline in Sprague-Dawley rats

In our previous study, oral administration of pentoxifylline, a drug used to improve blood flow, significantly reduced traction ability and induced a transient increase in body temperature in ICR mice.In this follow-up study, we evaluated the respiratory safety of oral pentoxifylline in Sprague-Dawley rats using wholebody plethysmography.Pentoxifylline was administered at three dose levels (10, 30, and 100 mg/kg), while a control group received a vehicle solution (0.5% carboxymethyl cellulose sodium salt in distilled water).Respiratory rate, tidal volume, and minute volume were measured at multiple time points (0, 0.5, 1, 2, 4, 6 h) following oral administration of pentoxifylline.No significant, dose-dependent changes were observed in any respiratory parameters, with all values remaining within normal physiological limits.In conclusion, a single oral dose of pentoxifylline did not adversely affect respiratory function, supporting its safety for clinical applications.