Cyclooxygenase-2 negatively regulates osteogenic differentiation in murine bone marrow mesenchymal stem cells via the FOXO3a/p27<sup>kip1</sup> pathway
Together with the findings from previous and current studies, these results indicate that COX-2 has a different role in proliferation versus differentiation during osteogenesis via FOXO3a/p27<sup>kip1</sup> signalling in osteoblasts or BMSCs.
Authors
- Chung‐Hwan Chen (ORCID: https://orcid.org/0000-0001-8941-4792)
- Mei‐Ling Ho (ORCID: https://orcid.org/0000-0001-8064-8488)
- Ya‐Shuan Chou (ORCID: https://orcid.org/0000-0002-0462-895X)
- Je‐Ken Chang (ORCID: https://orcid.org/0000-0001-8485-2574)
- Shu‐Chun Chuang (ORCID: https://orcid.org/0000-0002-3590-7775)
- Yi-Shan Lin
Institutions
- National Sun Yat-sen University (TW)
- Kaohsiung Medical University (TW)
- Kaohsiung Medical University Chung-Ho Memorial Hospital (TW)
Publication Details
- Journal
- Bone and Joint Research
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1302/2046-3758.145.bjr-2024-0262.r2
- Citations
- 2
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Kaohsiung Medical University
- National Health Research Institutes