Streptospherin A, a New Cancer Stem Cell Inhibitor, Produced by <i>Streptomyces</i> sp. KUSC-240
Cancer stem cells (CSCs) are a major cause of tumor recurrence; therefore, using CSC inhibitors is a potential strategy for cancer chemotherapy. We used our previously reported screening system that targets CSCs to identify a new scarce compound, streptospherin A (1), isolated from Streptomyces sp. KUSC-240. The planar structure of 1 was determined by high-resolution-MS (HR-MS) and NMR analysis. Nuclear Overhauser effect spectroscopy correlation and J-resolved heteronuclear multiple bond connectivity analysis revealed the partial relative configuration on the tetrahydropyran ring. Streptospherin A (1) inhibited CSC sphere formation and suppressed the growth of CSCs. These results suggest that streptospherin A (1) is a potential anticancer agent that may target CSCs.
Authors
- Hiroaki Ikeda (ORCID: https://orcid.org/0000-0002-8012-4796)
- Kayo Funayama
- Manabu Shibasaki (ORCID: https://orcid.org/0000-0001-5707-2871)
- Masaya Imoto (ORCID: https://orcid.org/0000-0003-4910-3871)
- Saki Makita
- Kazutoshi Shindo (ORCID: https://orcid.org/0000-0002-9281-0822)
- Hideaki Kakeya (ORCID: https://orcid.org/0000-0002-4293-7331)
- Takefumi Kuranaga (ORCID: https://orcid.org/0000-0003-2566-2038)
- Taiki Suo
- Kazuo Furihata
- A. Mimura
- Saya Yoshida
Institutions
- Keio University (JP)
- Kyoto University (JP)
- Japan Women's University (JP)
- Juntendo University (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Chemical and Pharmaceutical Bulletin
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1248/cpb.c25-00097
- Citations
- 1
- Primary Topic
- Chemical Reactions and Isotopes
- Type
- article
- Field-Weighted Citation Impact
- 0.79
Funders
- Japan Agency for Medical Research and Development
- Ministry of Education, Culture, Sports, Science and Technology