Long-read sequencing reveals novel isoform-specific eQTLs and regulatory mechanisms of isoform expression in human B cells
These findings highlight the substantial contribution of ieQTLs identified through long-read analysis in our understanding of the functional implications of genetic variations and the regulatory mechanisms governing isoforms.
Authors
- Mihoko Shimada (ORCID: https://orcid.org/0000-0001-8511-6640)
- Ko Ikemoto
- Akihiro Fujimoto (ORCID: https://orcid.org/0000-0002-0075-0800)
- Ryoji Kuribayashi
- Tadashi Kaname (ORCID: https://orcid.org/0000-0003-0281-9610)
- Hiroki Kiyose
- Motoko Unoki (ORCID: https://orcid.org/0000-0002-9629-3818)
- Arisa Igarashi (ORCID: https://orcid.org/0000-0001-7206-3105)
- Y. Nagura
Institutions
- National Center For Child Health and Development (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Genome biology
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1186/s13059-025-03583-w
- Citations
- 4
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 3.19
Funders
- Japan Agency for Medical Research and Development
- Takeda Foundation
- University of Tokyo