Enhanced CAR T-Cell Therapy for Lymphoma after Previous Failure
In this small study, huCART19-IL18 had a safety profile consistent with other CAR T-cell treatments and showed promising efficacy at low cell doses in patients with lymphoma after the failure of previous anti-CD19 CAR T-cell therapy. (ClinicalTrials.gov number, NCT04684563.).
Authors
- Joanne Shea (ORCID: https://orcid.org/0000-0003-4147-4301)
- Jakub Svoboda (ORCID: https://orcid.org/0000-0002-6359-7065)
- Wei‐Ting Hwang (ORCID: https://orcid.org/0000-0003-2829-2167)
- Don L. Siegel (ORCID: https://orcid.org/0000-0003-2098-2251)
- Carl H. June (ORCID: https://orcid.org/0000-0003-0241-3557)
- Saba Ghassemi (ORCID: https://orcid.org/0000-0002-2415-3576)
- Julia Han Noll (ORCID: https://orcid.org/0000-0003-3066-7378)
- Elise A. Chong (ORCID: https://orcid.org/0000-0001-8895-1625)
- Amanda Cervini (ORCID: https://orcid.org/0000-0002-1089-8737)
- Stefan Klaus Barta (ORCID: https://orcid.org/0000-0002-3280-5271)
- Gabriela Plesa (ORCID: https://orcid.org/0000-0002-4279-5943)
- Megan Four (ORCID: https://orcid.org/0000-0002-4031-9572)
- Vanessa Gonzalez (ORCID: https://orcid.org/0000-0003-3603-7457)
- Joseph A. Fraietta (ORCID: https://orcid.org/0000-0001-7900-8993)
- Andrew J. Rech (ORCID: https://orcid.org/0000-0002-6585-8839)
- Daniel J. Landsburg (ORCID: https://orcid.org/0000-0002-5077-4181)
- Luca Paruzzo (ORCID: https://orcid.org/0000-0002-6505-0194)
- James N. Gerson (ORCID: https://orcid.org/0000-0002-4736-187X)
- David L. Porter (ORCID: https://orcid.org/0000-0001-6333-9536)
- Anne Chew
- Michael Cook (ORCID: https://orcid.org/0000-0002-6171-9647)
- Edward Pequignot
- Julie K. Jadlowsky (ORCID: https://orcid.org/0009-0005-5115-1321)
- Stephen J. Schuster (ORCID: https://orcid.org/0000-0002-3376-8978)
- Sunita D. Nasta (ORCID: https://orcid.org/0000-0002-8981-2931)
- Marco Ruella (ORCID: https://orcid.org/0000-0003-4301-5811)
- Noelle V. Frey (ORCID: https://orcid.org/0000-0003-3688-9836)
- Rachel Leskowitz (ORCID: https://orcid.org/0000-0003-0583-8446)
- John Scholler (ORCID: https://orcid.org/0000-0002-9725-6277)
- Elizabeth Olson Hexner (ORCID: https://orcid.org/0000-0002-1125-4060)
- Megan M. Davis
- Amy Marshall
- Bruce L. Levine
- Juliana Rojas-Levine
Institutions
- University of Vermont Medical Center (US)
- Parker Institute for Cancer Immunotherapy (US)
- UPMC Hillman Cancer Center (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1056/nejmoa2408771
- Citations
- 72
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 75.27
Funders
- University of Pennsylvania