Development of Photopolymerizable Implants for Controlled Release of Pro-Apoptotic 1,2,4-Oxadiazoles

We present a study on developing photopolymerizable implants for the controlled release of pro-apoptotic 1,2,4-oxadiazoles to enhance their efficacy and safety in cancer treatment. The research focuses on synthesizing, testing, and incorporating 3,5-diaryl-1,2,4-oxadiazoles into a polymeric matrix based on methacrylates and utilizing these photopolymerizable devices for cancer therapy. Swelling tests showed that while the resin swells in contact with liquids, the presence of oxadiazole slowed this swelling, leading to a prolonged drug release over 50 days. The implant retained the cytotoxic activity of the isolated drug, indicating its potential for cancer therapy.