Association of Hypoxemia Due to Obstructive Sleep Apnea With White Matter Hyperintensities and Temporal Lobe Changes in Older Adults
These findings identify CSVD as a candidate mechanism linking OSA-related hypoxemia to MTL degeneration and impaired sleep-dependent memory in older adults, specifically implicating hypoxic events during REM sleep.
Authors
- Ivy Y. Chen (ORCID: https://orcid.org/0000-0002-6739-3211)
- Negin Sattari (ORCID: https://orcid.org/0000-0002-3974-9030)
- Batool Rizvi (ORCID: https://orcid.org/0000-0001-9120-3943)
- Bryce A. Mander (ORCID: https://orcid.org/0000-0002-0831-7980)
- Kitty K. Lui (ORCID: https://orcid.org/0000-0001-7586-0118)
- Miranda G Chappel-Farley (ORCID: https://orcid.org/0000-0003-1349-0507)
- Abhishek Dave (ORCID: https://orcid.org/0000-0002-6186-027X)
- Ruth M. Benca (ORCID: https://orcid.org/0000-0002-5895-817X)
- Ariel B. Neikrug (ORCID: https://orcid.org/0000-0001-8119-6380)
- Destiny Berisha (ORCID: https://orcid.org/0000-0002-9554-9666)
- Nicholas J. Tustison (ORCID: https://orcid.org/0000-0001-9418-5103)
- Michael A. Yassa (ORCID: https://orcid.org/0000-0002-8635-1498)
- David B. Keator (ORCID: https://orcid.org/0000-0001-5281-5576)
- Lisa Taylor (ORCID: https://orcid.org/0000-0002-8437-3159)
- John C. Janecek
Institutions
- University of Wisconsin–Madison (US)
- University of Pittsburgh (US)
- University of California, Irvine (US)
- San Diego State University (US)
- University of California San Diego (US)
- Wake Forest University (US)
Publication Details
- Journal
- Neurology
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1212/wnl.0000000000213639
- Citations
- 9
- Primary Topic
- Obstructive Sleep Apnea Research
- Type
- article
- Field-Weighted Citation Impact
- 10.48