Outcomes of Radium-223 and Stereotactic Ablative Radiotherapy Versus Stereotactic Ablative Radiotherapy for Oligometastatic Prostate Cancers: The RAVENS Phase II Randomized Trial
Adding Ra223 to SABR MDT in BM omCSPC does not delay progression of disease. We provide evidence for an HiRi mutational signature and TCR repertoire as prognostic biomarkers in omCSPC treated with SABR MDT, highlighting the importance of collecting biological correlates in RCTs for omCSPC.
Authors
- Samuel Ray Denmeade (ORCID: https://orcid.org/0000-0001-5442-515X)
- Michael A. Carducci (ORCID: https://orcid.org/0000-0002-7908-1215)
- Theodore L. DeWeese (ORCID: https://orcid.org/0000-0002-2447-2120)
- Reem Malek (ORCID: https://orcid.org/0000-0001-5346-1431)
- Sean S. Park (ORCID: https://orcid.org/0000-0003-3814-853X)
- Jarey H. Wang (ORCID: https://orcid.org/0000-0001-9038-4674)
- Matthew Pierre Deek (ORCID: https://orcid.org/0000-0002-5949-5058)
- Philip Anthony Sutera (ORCID: https://orcid.org/0000-0002-4021-5909)
- James L. Leenstra (ORCID: https://orcid.org/0000-0002-0863-4070)
- Ryan Phillips
- Chad Z. Tang (ORCID: https://orcid.org/0000-0002-5915-1327)
- Alexander D. Sherry (ORCID: https://orcid.org/0000-0001-5115-1691)
- Bradley J. Stish (ORCID: https://orcid.org/0000-0003-2752-0607)
- Stephen Greco (ORCID: https://orcid.org/0000-0003-3667-1044)
- Matthew Ramotar (ORCID: https://orcid.org/0000-0003-4179-0523)
- Orhan K. Öz (ORCID: https://orcid.org/0000-0002-5846-6829)
- Daniel Y. Song (ORCID: https://orcid.org/0000-0002-3495-8677)
- Catherine Handy Marshall (ORCID: https://orcid.org/0000-0002-2653-4110)
- Curtiland Deville (ORCID: https://orcid.org/0000-0003-4846-6486)
- Shirl Dipasquale
- Jiayun Lu (ORCID: https://orcid.org/0000-0002-5592-6658)
- Matthew C. Abramowitz (ORCID: https://orcid.org/0000-0002-2632-579X)
- Phuoc T. Tran (ORCID: https://orcid.org/0000-0002-0147-0376)
- Ana P. Kiess (ORCID: https://orcid.org/0000-0001-6928-3852)
- Soha Bazyar
- Neil Bipinchandra Desai (ORCID: https://orcid.org/0000-0002-6287-3427)
- S.A. Dudley
- Noura Radwan (ORCID: https://orcid.org/0000-0002-3511-0125)
- Alejandro Berlín (ORCID: https://orcid.org/0000-0002-1880-6905)
- Kenneth J. Pienta (ORCID: https://orcid.org/0000-0002-4138-2186)
- Channing Judith Paller (ORCID: https://orcid.org/0000-0003-3658-1858)
- Hao Wang (ORCID: https://orcid.org/0000-0001-6489-6940)
- Robert F. Hobbs (ORCID: https://orcid.org/0000-0002-1328-7114)
- Emmanuel S. Antonarakis (ORCID: https://orcid.org/0000-0003-0031-9655)
Institutions
- Rutgers, The State University of New Jersey (US)
- University of Maryland, Baltimore (US)
- The University of Texas MD Anderson Cancer Center (US)
- Johns Hopkins University (US)
- University of Miami (US)
- Johns Hopkins Medicine (US)
- Princess Margaret Cancer Centre (CA)
- University of Rochester Medical Center (US)
- Mayo Clinic in Arizona (US)
- University of Minnesota Medical Center (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1200/jco-25-00131
- Citations
- 16
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 24.29