Identification of Distinct Biological Groups of Patients With Cryptogenic NORSE via Inflammatory Profiling
The identification of distinct inflammatory subgroups in c-NORSE suggests that variations in the underlying immune mechanisms contribute to differential treatment responses. These findings underscore the importance of personalized therapeutic strategies, potentially targeting specific inflammatory pathways, to optimize clinical outcomes in this challenging condition.
Authors
- Nicolas Gaspard (ORCID: https://orcid.org/0000-0003-1148-6723)
- Nathan Torcida (ORCID: https://orcid.org/0009-0004-6208-5035)
- Ayush Batra (ORCID: https://orcid.org/0000-0002-4783-5801)
- Onome Eka (ORCID: https://orcid.org/0000-0002-4294-8292)
- Mariel Kalkach Aparicio (ORCID: https://orcid.org/0000-0002-3509-3548)
- Aurélie Hanin (ORCID: https://orcid.org/0000-0002-5912-9998)
- Olga D. Taraschenko (ORCID: https://orcid.org/0000-0003-4848-8909)
- Stephen Hantus (ORCID: https://orcid.org/0000-0003-0037-753X)
- Teneille Gofton (ORCID: https://orcid.org/0000-0001-9001-4884)
- Aaron F. Struck (ORCID: https://orcid.org/0000-0002-9103-1798)
- Karnig Kazazian (ORCID: https://orcid.org/0000-0001-6157-601X)
- Charles L. Howe (ORCID: https://orcid.org/0000-0002-3889-8739)
- Sophie Demeret (ORCID: https://orcid.org/0000-0002-0523-6472)
- Minjee Kim (ORCID: https://orcid.org/0000-0002-2720-1940)
- Clémence Marois (ORCID: https://orcid.org/0000-0002-3266-0623)
- Mario Chávez (ORCID: https://orcid.org/0000-0003-0390-4833)
- Elizabeth E. Gerard (ORCID: https://orcid.org/0000-0003-3062-8360)
- Ji Yeoun Yoo (ORCID: https://orcid.org/0000-0001-7242-9779)
- Maysaa Basha (ORCID: https://orcid.org/0000-0003-1561-1667)
- Alexandra Martín Ramírez (ORCID: https://orcid.org/0000-0002-1132-2211)
- Andrew L. Mellor (ORCID: https://orcid.org/0000-0002-9553-6160)
- Krista Eschbach (ORCID: https://orcid.org/0000-0002-4249-338X)
- Brandon Foreman (ORCID: https://orcid.org/0000-0002-5418-674X)
- Wazim Mohamed (ORCID: https://orcid.org/0000-0002-9768-5178)
- Annamaria Vezzani (ORCID: https://orcid.org/0000-0003-0573-6175)
- Vincent Navarro (ORCID: https://orcid.org/0000-0003-0077-8114)
- Amy C. Jongeling (ORCID: https://orcid.org/0000-0001-6218-0869)
- Claude Steriade (ORCID: https://orcid.org/0000-0001-6799-9005)
- Yi‐Chen Lai (ORCID: https://orcid.org/0000-0002-9450-5506)
- Padmaja Kandula (ORCID: https://orcid.org/0000-0002-0676-7312)
- Lawrence J. Hirsch (ORCID: https://orcid.org/0000-0002-6333-832X)
- Hiba A. Haider (ORCID: https://orcid.org/0000-0001-7118-3690)
- Mark S. Wainwright (ORCID: https://orcid.org/0000-0002-4736-7462)
- Firas Kobeissy (ORCID: https://orcid.org/0000-0002-5008-6944)
- Martin Guillemaud (ORCID: https://orcid.org/0009-0002-2523-8712)
- Kevin Wang (ORCID: https://orcid.org/0000-0002-9343-6473)
- Anthony D. Jimenez
- M. Morales
- Cederic M. Pimentel
Institutions
- Northwestern University (US)
- Western University (CA)
- Centre National de la Recherche Scientifique (FR)
- Seattle Children's Hospital (US)
- Cleveland Clinic (US)
- Université Libre de Bruxelles (BE)
- Institut national de recherche en sciences et technologies du numérique (FR)
- University of Wisconsin–Madison (US)
- Emory University (US)
- Inserm (FR)
- Baylor College of Medicine (US)
- Wayne State University (US)
- Mario Negri Institute for Pharmacological Research (IT)
- University of Washington (US)
- Université Paris Cité (FR)
- Cornell University (US)
- Erasmus Hospital (BE)
- Yale University (US)
- Sorbonne Université (FR)
- University of Chicago (US)
- NYU Langone Health (US)
- Sorbonne Paris Cité (FR)
- Children's Hospital Colorado (US)
- Assistance Publique – Hôpitaux de Paris (FR)
- Pitié-Salpêtrière Hospital (FR)
- Mayo Clinic in Arizona (US)
- Institut du Cerveau (FR)
- The Neurological Institute (US)
- Weill Cornell Medicine (US)
- University of Nebraska Medical Center (US)
- University of Cincinnati (US)
- Morehouse School of Medicine (US)
- University of Colorado Denver (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1212/nxi.0000000000200403
- Citations
- 13
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 10.48