Identification and Structural Elucidation of a Novel Pyrrolidinophenone-Based Designer Drug on the Illicit Market: α-BPVP
The identification of a new psychoactive substances (NPS) with a cathinone structure and a biphenyl substituent, found in seized powder from the black market, is here reported. By combining analytical techniques, including 1D and 2D NMR and HRMS, the compound was identified as 1-([1,1'-biphenyl]-4-yl)-2-(pyrrolidin-1-yl)pentan-1-one (α-BPVP), an α-pyrrolidinopentiophenone (α-PVP) analogue featuring a biphenyl group instead of the phenyl ring. This previously unreported molecule raises urgent legal and public health concerns, which warrants further toxicological investigation.
Authors
- Paola Rota (ORCID: https://orcid.org/0000-0001-5795-4989)
- Sara Casati (ORCID: https://orcid.org/0000-0002-5049-7321)
- Riccardo Primavera
- Roberta F. Bergamaschi (ORCID: https://orcid.org/0000-0002-7533-1934)
- Alessandro Ravelli
- Gabriella Roda (ORCID: https://orcid.org/0000-0002-6736-6467)
- Alessio Battistini (ORCID: https://orcid.org/0000-0001-6007-0658)
- Ivana Lavota
- Chiara Ciccarelli
- Claudio Guidotti
Institutions
- University of Milan (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Center for Translational Molecular Medicine (NL)
- PromoFirenze (IT)
Publication Details
- Journal
- Chemical Research in Toxicology
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1021/acs.chemrestox.5c00068
- Citations
- 2
- Primary Topic
- Forensic Toxicology and Drug Analysis
- Type
- article
- Field-Weighted Citation Impact
- 2.61