General Anesthesia–activated Neurons in the Central Amygdala Mediate Antinociception: Distinct Roles in Acute versus Chronic Phases of Nerve Injury
These results validate the antinociceptive power of CeA GA neurons using a different approach. Additionally, the authors highlight distinct roles of CeA GA neurons in governing physiologic pain, acute pain, and the transition to chronic pain through KCC2 dysregulation.
Authors
- Junli Zhao (ORCID: https://orcid.org/0000-0003-4751-3172)
- Joseph P. Mathew (ORCID: https://orcid.org/0000-0002-3815-4131)
- Ru‐Rong Ji (ORCID: https://orcid.org/0000-0002-9355-3688)
- Kenta Furutani (ORCID: https://orcid.org/0000-0002-1893-4384)
- Aidan McGinnis (ORCID: https://orcid.org/0000-0002-9146-2205)
- Fan Wang (ORCID: https://orcid.org/0000-0003-2988-0614)
Institutions
- McGovern Institute for Brain Research (US)
- Duke University (US)
- Duke Medical Center (US)
- Duke University Hospital (US)
- Massachusetts Institute of Technology (US)
Publication Details
- Journal
- Anesthesiology
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1097/aln.0000000000005553
- Citations
- 3
- Primary Topic
- Anesthesia and Sedative Agents
- Type
- article
- Field-Weighted Citation Impact
- 6.57