[Serological and Molecular Biological Detection of RhD Variants].

<i>RHD</i> genotype testing of samples that are serologically negative for RhD antigen shows that some of the samples have <i>RHD</i> gene variants, not all of which are total deletions of <i>RHD</i>, suggesting that there are some limitations of the serologic method for RhD detection. Due to the polymorphism of the <i>RHD</i> gene structure, different RhD variants present different serologic features, which need to be further detected in combination with molecular biology testing, especially for the identification of Asian-type DELs, which is important for clinical precision blood transfusion.