[The Association of Polymorphisms Drug Metabolism and Transport of Imatinib Related Gene with Severe Hematology Adverse Effects in Chronic Myeloid Leukemia Patients].
Peripheral blood WBC, EOS%, Hb and HCT in patients with newly diagnosed CML-CP are all related to the risk of severe hematology AEs. <i>ABCB1</i> gene rs1045642 and <i>NR1I2</i> gene rs3814055 related to the metabolism and transport pathway of IM are associated with severe hematology AEs after IM treatment in CML-CP patients, and they may be potential molecular markers to predict the risk of severe hematology AEs of CML patients treated by IM.
Authors
- Wenjing Zhou (ORCID: https://orcid.org/0000-0002-4932-9312)
- Lijuan Wu (ORCID: https://orcid.org/0000-0002-0390-1782)
- Nian Wang (ORCID: https://orcid.org/0000-0002-8303-0365)
- Yuanxin Ye (ORCID: https://orcid.org/0000-0003-2915-7493)
- Lin Li (ORCID: https://orcid.org/0000-0002-2310-2398)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-04-01
- DOI
- https://doi.org/10.19746/j.cnki.issn.1009-2137.2025.02.006
- Primary Topic
- Chronic Myeloid Leukemia Treatments
- Type
- article