NaV1.5 or KCa2 channel blockade does not increase arrhythmia risk in hypokalemic rabbit hearts, unlike KV11.1 inhibition with dofetilide
These findings suggests that K<sub>Ca</sub>2 channels have minimal importance for ventricular repolarization in healthy rabbit hearts under both normo- and hypokalemic conditions.
Authors
- Ulrik S. Sørensen (ORCID: https://orcid.org/0000-0002-2926-0012)
- Anders G. Holst (ORCID: https://orcid.org/0000-0002-5343-7367)
- Sofia Hammami Bomholtz (ORCID: https://orcid.org/0000-0001-7221-4532)
- Lea Abildgaard
- Mark Alexander Skarsfeldt (ORCID: https://orcid.org/0000-0003-4765-9243)
- Bo Hjorth Bentzen (ORCID: https://orcid.org/0000-0002-0253-4992)
- Jonas Goldin Diness (ORCID: https://orcid.org/0000-0002-5828-8233)
- Morten Grunnet (ORCID: https://orcid.org/0000-0001-5909-3625)
- Yannan Yan
Institutions
- University of Copenhagen (DK)
- Acesion Pharma (Denmark) (DK)
Publication Details
- Journal
- IJC Heart & Vasculature
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1016/j.ijcha.2025.101699
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.00