Melatonin alleviates sepsis-induced acute lung injury by inhibiting necroptosis via reducing circulating mtDNA release
Melatonin mitigates sepsis-induced ALI by suppressing necroptosis through inhibition of STING activation and reduction of mtDNA release. These findings suggest melatonin as a potential therapeutic strategy for sepsis-induced ALI.
Authors
- Zedazhong Su (ORCID: https://orcid.org/0000-0003-3168-687X)
- Lingyu Wei (ORCID: https://orcid.org/0000-0002-9947-4569)
- Suxin Luo (ORCID: https://orcid.org/0000-0003-4524-5979)
- Minghao Luo (ORCID: https://orcid.org/0000-0002-1044-8621)
- Jia Xu (ORCID: https://orcid.org/0000-0002-1091-8558)
- Xuebiao Wei (ORCID: https://orcid.org/0000-0002-1279-9441)
- Yuce Peng (ORCID: https://orcid.org/0000-0002-2095-8713)
- Zhonghua Wang (ORCID: https://orcid.org/0000-0001-5470-3092)
- Shenglong Chen (ORCID: https://orcid.org/0000-0001-6368-7346)
Institutions
- Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1186/s10020-025-01228-z
- Citations
- 6
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 4.78
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province