Carboxylic Acid- and Amine-Modified Pluronic F127-Based Thermoresponsive Nanogels as Smart Carriers for Brain Drug Delivery
Positively charged drug carrier nanomaterials demonstrate a higher propensity for transfer through the BBB, significantly expanding the applicability of positively charged EDF127 nanogels as nanocarriers for in vivo brain tissue treatment and imaging. Therefore, owing to their increased permeability across the BBB, carboxylic acid- and amine-modified Pluronic F127 nanogels (EDF127 and ADF127) will also offer a promising approach for brain tissue treatment and imaging.
Authors
- Tsung-Yun Wu
- Abegaz Tizazu Andrgie (ORCID: https://orcid.org/0000-0002-1758-6074)
- Horng‐Jyh Harn (ORCID: https://orcid.org/0000-0001-6777-3284)
- Hsieh‐Chih Tsai (ORCID: https://orcid.org/0000-0002-7034-6205)
- Yu-Shuan Chen
- Shinn‐Zong Lin (ORCID: https://orcid.org/0000-0002-4601-9933)
- Hsueh‐Hui Yang (ORCID: https://orcid.org/0000-0002-3432-7058)
- Chi-Han Liao
Institutions
- Debre Berhan University (ET)
- Chung Yuan Christian University (TW)
- National Taiwan University of Science and Technology (TW)
- Tzu Chi University (TW)
- Tzu Chi Foundation (TW)
- Hualien Tzu Chi Medical Center (TW)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-05-01
- DOI
- https://doi.org/10.2147/ijn.s507362
- Citations
- 2
- Primary Topic
- Nanoparticle-Based Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 1.19
Funders
- National Science and Technology Council