Peunipyrone A, an Unexpected Highly Oxygenated γ-Pyrone with a 6/6/6/6/6 Pentacyclic Ring System from a Sponge-Derived Fungus <i>Aspergillus peuniceus</i>
A highly oxygenated γ-pyrone with an unprecedented carbon skeleton, peunipyrone A (<b>1</b>), was isolated from the sponge-derived fungus <i>Aspergillus peuniceus</i>. Compound <b>1</b> features a unique fused 6/6/6/6/6 pentacyclic ring system. The chemical structure of compound <b>1</b> was elucidated by comprehensive spectroscopic techniques and single-crystal X-ray diffraction. The plausible biosynthetic pathway of compound <b>1</b> was proposed. Compound <b>1</b> promoted leukemic cell apoptosis by increasing p53 expression.
Authors
- Peitao Zhang
- Tongmei Xiao
- Jian Yuan (ORCID: https://orcid.org/0000-0002-2801-8849)
- Ruifang Zheng (ORCID: https://orcid.org/0000-0002-1287-5029)
- Lian Li (ORCID: https://orcid.org/0000-0003-4700-1134)
- Minghua Chen (ORCID: https://orcid.org/0000-0001-5634-4599)
- Yu‐Chuan Chen (ORCID: https://orcid.org/0000-0003-1723-3567)
- Bingjie Su
- Shuyue Guo (ORCID: https://orcid.org/0000-0002-4780-2794)
- Mingxuan Zhao
- Shuyi Si
Institutions
- Tongji University (CN)
- Biotechnology Institute (US)
- University of Toronto (CA)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Lunenfeld-Tanenbaum Research Institute (CA)
- Peking Union Medical College Hospital (CN)
- Xinjiang Institute of Materia Medica (CN)
- Shanghai East Hospital (CN)
- Sinai Health System (US)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1021/acs.orglett.5c01274
- Citations
- 3
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- National Natural Science Foundation of China
- Chinese Academy of Medical Sciences