Prospective Associations Between Structural Brain Development and Onset of Depressive Disorder During Adolescence and Emerging Adulthood
Relative increases in amygdala volume and temporal, insula, and occipital cortical thickness across adolescence may reflect disturbances in brain development, contributing to depression onset. This raises the possibility that prior findings of reduced gray matter in clinically depressed individuals instead reflect alterations that are caused by disorder-related factors after onset.
Authors
- Julian G. Simmons (ORCID: https://orcid.org/0000-0002-7228-1847)
- Nandita Vijayakumar (ORCID: https://orcid.org/0000-0002-5622-9547)
- Orli Schwartz (ORCID: https://orcid.org/0000-0001-7634-3737)
- Nicholas B. Allen (ORCID: https://orcid.org/0000-0002-1086-6639)
- Sarah Whittle (ORCID: https://orcid.org/0000-0003-3145-1528)
- Divyangana Rakesh (ORCID: https://orcid.org/0000-0002-8529-2086)
Institutions
- Mental Health Research Institute (AU)
Publication Details
- Journal
- American Journal of Psychiatry
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1176/appi.ajp.20240588
- Citations
- 5
- Primary Topic
- Child and Adolescent Psychosocial and Emotional Development
- Type
- article
- Field-Weighted Citation Impact
- 11.53