Altered BAG3-insulin colocalization is associated with impaired first phase insulin secretion in humans
BAG3 appears associated to first-phase insulin secretion in humans by influencing insulin granule exocytosis. Targeting BAG3 could represent a novel therapeutic approach to prevent or delay β-cell dysfunction and the onset of T2DM.
Authors
- Francesco Pizzo (ORCID: https://orcid.org/0000-0002-9937-1367)
- Doriana Fruci (ORCID: https://orcid.org/0000-0003-3388-7296)
- Erika Pizzinato (ORCID: https://orcid.org/0009-0005-7352-0028)
- Vincenzo De Laurenzi (ORCID: https://orcid.org/0000-0002-7506-1743)
- Giuseppe Quero (ORCID: https://orcid.org/0000-0002-0001-9479)
- Gea Ciccarelli (ORCID: https://orcid.org/0009-0001-3621-6298)
- Gianfranco Di Giuseppe (ORCID: https://orcid.org/0000-0003-4506-5193)
- Laura Soldovieri (ORCID: https://orcid.org/0009-0001-3315-0406)
- Verena Damiani (ORCID: https://orcid.org/0000-0003-2833-841X)
- Michela Brunetti (ORCID: https://orcid.org/0009-0008-0139-4749)
- Teresa Mezza (ORCID: https://orcid.org/0000-0001-5407-9576)
- Andrea Giaccari (ORCID: https://orcid.org/0000-0002-7462-7792)
- Alfredo Pontecorvi (ORCID: https://orcid.org/0000-0003-0570-6865)
- Andrea Mari (ORCID: https://orcid.org/0000-0002-1436-5591)
- Sergio Alfieri (ORCID: https://orcid.org/0000-0002-8057-0788)
- Giulia Gliozzo (ORCID: https://orcid.org/0009-0002-1065-6030)
Institutions
- Università Cattolica del Sacro Cuore (IT)
- Agostino Gemelli University Polyclinic (IT)
- University of Chieti-Pescara (IT)
- Bambino Gesù Children's Hospital (IT)
- University of the Sacred Heart (JP)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- National Research Council (IT)
Publication Details
- Journal
- Diabetes Research and Clinical Practice
- Published
- 2025-05-07
- DOI
- https://doi.org/10.1016/j.diabres.2025.112232
- Citations
- 1
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Università Cattolica del Sacro Cuore
- Ministero dell'Università e della Ricerca