Lacticaseibacillus casei is a promising contender for fighting multi-drug-resistant/extensively-drug-resistant Enterobacteriaceae and Pseudomonas in foods

BackgroundUlcerative colitis (UC) is a type of chronic inflammatory bowel disease in the colon that is still of unknown aetiology.What is known, till now, is that UC is confined to the colon starting at the rectum and extending proximally for a variable distance till reaching the cecum, and despite UC is known to have various extracolonic presentations, the upper gastrointestinal tract (UGIT) is not generally considered as a target organ. AimThe current study aimed to describe UGIT clinical, endoscopic, and histopathological findings in adult Egyptian patients with UC. Patients and methodsThe study was conducted on 56 UC patients.In the Tropical Medicine Department Faculty of Medicine, Ain Shams University.All the patients were subjected to full history taking and thorough clinical examination.UGIT endoscopy was performed on all patients to study the endoscopic findings in the oesophagus, stomach, and duodenum and to take biopsies for histopathological examination. ResultsThe current study has shown that 60.7% of patients had gastroesophageal reflux disease upon esophagogastroduodenoscopy while microscopic evaluation of oesophageal biopsies showed that 50% of the cases were having esophagitis.Regarding gastroduodenal affection, UGIT endoscopy revealed that 91.1% of the patients had gastritis and 78.6% had duodenitis, histopathological examination of the biopsy samples revealed that 53.6% of the cases had chronic nonspecific gastritis, 33.9% of the cases showed chronic gastritis with helicobacter pylori infection and 85.7% had chronic nonspecific duodenitis.The present study showed that UGIT affection was diagnosed collectively in 96.4 and 87.5% of the cases by endoscopy and biopsy, respectively. ConclusionThe current study has proved the association between UC and the presence of endoscopic findings in the oesophagus, stomach, and duodenum.These findings were confirmed by histopathological examination of mucosal biopsies taken from the oesophagus, stomach, and duodenum.