Comprehensive screening of potential inhibitors from ZINC15 database for Metallo-L1 Β -Lactamase from Stenotrophomonas maltophilia via in Silico and in vitro approaches
The study validates a promising compound for overcoming resistance caused by L1 β-lactamase in Stenotrophomonas maltiphilia. These results highlight the potential of combining computational and experimental approaches to develop novel therapies. The findings provide a foundation for future strategies targeting β-lactamase-mediated resistance in Stenotrophomonas maltophilia.
Authors
- Shobana Sugumar (ORCID: https://orcid.org/0000-0002-9975-670X)
- K. H. Sreenithya
- Salim Manoharadas (ORCID: https://orcid.org/0000-0002-1875-5976)
Institutions
- SRM Institute of Science and Technology (IN)
- King Saud University (SA)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2025-05-06
- DOI
- https://doi.org/10.1186/s12866-025-03994-6
- Primary Topic
- Infections and bacterial resistance
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- SRM Institute of Science and Technology
- King Saud University