Differential activation of monocytes and PMNs in orofacial granulomatosis patients induced by bacterial and non-bacterial stimuli
These preliminary data suggest that in presence of various stimuli, monocytes and PMNs of OFG patients displayed an activated phenotype compared to HDs. Unraveling the interplay between bacterial triggers and immune cell function in OFG will be necessary to elucidate mechanisms driving this complex disease and identify novel therapeutic targets for improved management of OFG patients.
Authors
- Anne Lise Ferrara (ORCID: https://orcid.org/0000-0003-1839-8873)
- Francesca Wanda Rossi (ORCID: https://orcid.org/0000-0002-5430-032X)
- Amato de Paulis (ORCID: https://orcid.org/0000-0003-0347-2540)
- Annagioia Ventrici
- Angelica Petraroli (ORCID: https://orcid.org/0000-0001-5700-7164)
- Maria Rosaria Galdiero (ORCID: https://orcid.org/0000-0002-8086-9130)
- Remo Poto (ORCID: https://orcid.org/0000-0002-4723-0167)
- Leonardo Cristinziano (ORCID: https://orcid.org/0000-0002-7835-2212)
- Francesco Palestra (ORCID: https://orcid.org/0000-0001-6145-7475)
- Luca Modestino (ORCID: https://orcid.org/0000-0003-2063-7124)
- Gilda Varricchi (ORCID: https://orcid.org/0000-0002-9285-4657)
- Stefania Loffredo (ORCID: https://orcid.org/0000-0002-5871-1898)
- Giuseppe Spadaro (ORCID: https://orcid.org/0000-0001-7889-425X)
- Gianni Marone (ORCID: https://orcid.org/0000-0002-9849-4701)
- Gina Memoli
- Arianna Monteforte
Institutions
- Federico II University Hospital (IT)
- Institute for Experimental Endocrinology and Oncology (IT)
- National Research Council (IT)
- University of Naples Federico II (IT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-06
- DOI
- https://doi.org/10.3389/fimmu.2025.1522495
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Università degli Studi di Napoli Federico II
- Regione Campania
- Associazione Italiana per la Ricerca sul Cancro